Following the Muslim conquest of the Levant, the city passed to the Umayyads in 661 AD and the Abbasids in 750. It was ravaged several times during the Arab–Byzantine wars. After the disintegration of the Abbasid dynasty, the city was ruled successively by the Tulunids, the Ikhshidids and the Hamdanids. In 962, it was recaptured by the Byzantines.

The Anatolian Seljuks took Aintab in 1067. They gave way to the Syrian Seljuks in 1086. Tutush I appointed Thoros of Edessa as governor of the region.